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Deep smile folds (also known as nasolabial folds) are the large visible folds that run from the corner of the nose to the corner of the mouth. Facial structure and genetic factors partially determine the prominence and depth of nasolabial folds. Although they are more exaggerated when smiling as aging occurs, they may appear more permanent and deeper and contribute to a "sagging" appearance, causing the face to look tired or drawn.
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